Best Diaper Rash Cream (Top 10 Reviews)

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For some new parents, babies are easy and breezy. And for others, they’ve got 99 problems and diaper rash is one of them. That’s why finding the best diaper rash cream is so important.

There are many quality brands of rash cream out there, each one with their own unique formulations that are designed to bring safe and effective relief to your baby.

Let’s take a look at the 10 best creams so you can choose the right one for your baby’s tender bottom.

Top 10 Picks

Desitin Rapid Relief Diaper Rash Remedy


Desitin has been labeled as the top choice for diaper rash cream for pediatricians as well as moms. It has been shown in clinical trials to bring relief from diaper rash by soothing and healing diaper rash while providing moisturizing powers. Made with zinc oxide, this tube form of diaper rash cream creates an instant protective layer from the first use. It’s free of fragrances, hypoallergenic and tested by dermatologists so you can feel confident using it on your baby’s skin every day.

The smooth formula glides on with ease and wipes off just as easily while still being strong enough to provide overnight protection for more sound sleep.

Boudreaux’s Butt Paste


It’s got a funny name, but pediatricians recommend this brand of diaper rash cream because it is effective in treating and preventing rash. When skin becomes chafed, it protects it and locks out wetness to keep diaper rash from coming back. It has a delightful fragrance too that smells nothing like an ointment. This cream is formulated with 40% zinc oxide, making it the maximum strength treatment for your baby’s diaper rash.

Recognized by the FDA for effective diaper rash treatment, zinc oxide is a safe ingredient you can trust. Additionally, this rash cream is thick, providing a proper barrier to protect your child. The remaining ingredients aren’t harsh at all.

There are no dyes, parabens, preservatives, phthalates or talc to worry about here. It only has 6 ingredients in it, making it a choice parents can feel good about.

Weleda Diaper Care Cream with Calendula 2.8oz


From Germany, this dermatologist-tested cream is made with calendula extract. It comes from the brand Weleda’s biodynamic gardens and is certified natural by NaTrue. It was developed with German midwives and contains no phthalates, parabens or synthetic fragrances. And it isn’t tested on animals either.

This cream is rich and creamy with zinc oxide to give the perfect barrier against moisture. Other ingredients like sweet almond oil and sesame oil provide nourishment to pamper your baby’s delicate skin.

It doesn’t contain mineral oil and uses fair trade beeswax instead to give breathable protection to the skin. Additionally, adults can also benefit from this diaper rash cream by applying it to blemishes.

Era Organics Diaper Rash Cream


Era Organics makes this cream that is free of toxins. It’s USDA certified organic, effective and safe. This cream will soothe, repair and prevent chaffing and irritation from diaper rash thanks to a roster of proven ingredients that are natural. Ingredients include sunflower oil, cocoa butter, coconut oil, beeswax, olive oil, chamomile, and calendula, making for an antibacterial and antifungal protective barrier that truly works against rash without any skin damaging ingredients.

Plus, Era Organics will give you your money back if it doesn’t bring instant and long term relief to your baby’s diaper rash.

Triple Paste Medicated Ointment for Diaper Rash, 16-Ounce


This thick cream provides treatment and prevention of diaper rash. Formulated without fragrances and only using hypoallergenic ingredients, it works quickly to bring relief to delicate skin that is irritated from diaper rash. Even raw and chafed skin will find relief using this diaper rash ointment.

Dr. Smith’s On-the-Go Diaper Rash Spray, 3.5 Ounce


For on-the-go relief of diaper rash, this spray-on takes a hands off approach to treating diaper rash. There’s no mess to worry about. Simply pack in your bag and spray on as needed. It doesn’t need to be rubbed in afterward and will not cake up or run off. You’ll find that once you spray it, it stays put, adhering to your baby’s skin evenly to form a barrier against moisture and wetness. With safe ingredients for your baby and the environment, it’s a must-have for the diaper bag.

Aquaphor Baby Cream 3.5 Ounce


Aquaphor is recommended by pediatricians. It is free of preservatives and fragrances. The formula contains zinc oxide and panthenol to form a barrier to keep your baby’s skin protected all night, allowing for sound and restful sleep. It brings instant relief from diaper rash and soothes away irritation. This size tube is fantastic to tuck into your diaper bag so you’ll always have relief on hand for your baby’s diaper rash.

Desitin Baby Diaper Rash Maximum Strength Paste


This smaller tube version of Desitin’s maximum strength diaper rash cream formula is ideal for taking with you on the go. It’s the same great formulation with zinc oxide that is chosen by parents and pediatricians alike for instant and effective relief from diaper rash.

Weleda Baby White Mallow Cream


The certified natural German brand Weleda also makes this cream that is ideal for ultra-sensitive skin. It contains 86% organic ingredients that are effective in relieving and protecting diaper rash-prone skin. It works fast thanks to ingredients that mimic nature while containing a pharmaceutical-grade of zinc oxide, approved by the FDA for effective and safe treatment of diaper rash on baby skin. Ct which is ideal for soothing even the most sensitive skin.

It also contains organic coconut oil, revered for having a moisturizing effect that also lends a coolness to soothe away irritation and leave baby feeling comfortable again. As with the other formulation, there are no synthetic preservatives, added fragrances or colorants, and no mineral oils.

Balmex Diaper Rash Cream


Balmex presents this formulation of cream that fights the 3 main causes of diaper rash. It fights off wetness and protects from skin chaffing. It also keeps those pesky digestive enzymes that enter dirty diapers after the digestive process so that your baby’s skin won’t become further irritated. It is clinically proven to reduce diaper rash after one application, bringing soothing relief to your baby. Zinc oxide is in this pediatrician-recommended formula.

This formula for cream is effective yet easy to wipe off so you’ll always be able to comfort your baby’s skin. Once diaper rash is gone, you can use it to prevent future irritation, leading to more sound sleep and a happier baby.

Things to consider

All of these creams are effective and safe for treating diaper rash. However the one that you choose will depend on a few factors. For one, if organic certification is important to you, you’ll want to choose one of the organic options on our list of diaper rash creams. If a well-known brand is important to you, you’ll want to choose one of the big name brands on our list. If your baby has incredibly sensitive skin that becomes irritated with just about anything, choosing the natural line of formulations by Weleda may be your best bet. Ultimately, it could come down to trial and error as to which one works best on your baby.

Final thoughts

Don’t forget that every baby and every family is different. One brand may work beautifully for your baby but your best friend might not find it effective for her baby. It comes down to preferences, prices, and how much the diaper rash cream helps your baby find relief. You’ll know your baby feels better when he or she is sleeping through the night without waking for diaper changes. When you change the diaper, you’ll see a huge improvement in the appearance of the skin on your baby’s bottom and you’ll know you made the right choice for the best diaper cream.


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